Polynucleotides encoding anti-PD-L1 antibodies
AssigneeVentana Medical Systems, Inc.
InventorsMarcin Kowanetz, Hartmut Koeppen, Zachary Boyd, Zhiming Liao, Yifei Zhu, Bharathi Vennapusa, Patrick C. Roche
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Abstract
The invention provides programmed death-ligand 1 (PD-L1) antibodies and methods of using the same.
Claims21
An isolated nucleic acid encoding an antibody heavy chain variable domain (VH), wherein the VH comprises the following hypervariable regions (HVR-Hs):
- (a) an HVR-H1 comprising the amino acid sequence of SNGLT (SEQ ID NO:
- 2);
- (b) an HVR-H2 comprising the amino acid sequence of TINKDASAYYASWAKG (SEQ ID NO:
- 3);
- and
- (c) an HVR-H3 comprising the amino acid sequence of IAFKTGTSI (SEQ ID NO:
- 4).
An isolated nucleic acid encoding an antibody light chain variable domain (VL), wherein the VL comprises the following hypervariable regions (HVR-Ls):
- (a) an HVR-L1 comprising the amino acid sequence of QASESVYSNNYLS (SEQ ID NO:
- 9);
- (b) an HVR-L2 comprising the amino acid sequence of LASTLAS (SEQ ID NO:
- 10);
- and
- (c) an HVR-L3 comprising the amino acid sequence of IGGKSSSTDGNA (SEQ ID NO:
- 11).
An isolated nucleic acid encoding an antibody heavy chain variable domain (VH) and an antibody light chain variable domain (VL), wherein:
- the VH comprises the following heavy chain hypervariable regions (HVR-Hs):
- (a) an HVR-H1 comprising the amino acid sequence of SNGLT (SEQ ID NO:
- 2);
- (b) an HVR-H2 comprising the amino acid sequence of TINKDASAYYASWAKG (SEQ ID NO:
- 3);
- and
- (c) an HVR-H3 comprising the amino acid sequence of IAFKTGTSI (SEQ ID NO:
- 4);
- and
- the VL comprises the following light chain hypervariable regions (HVR-Ls):
- (d) an HVR-L1 comprising the amino acid sequence of QASESVYSNNYLS (SEQ ID NO:
- 9);
- (e) an HVR-L2 comprising the amino acid sequence of LASTLAS (SEQ ID NO:
- 10);
- and
- (f) an HVR-L3 comprising the amino acid sequence of IGGKSSSTDGNA (SEQ ID NO:
- 11).
Dependencies are inferred from the claim text.