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US 12,630,611 B2Granted
Anti-respiratory syncytial virus antibodies, methods of their generation and use
AssigneeMapp Biopharmaceutical, Inc.
InventorLaura M. Walker
Life of this patent
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Abstract
Provided are antibodies or antigen binding polypeptides characterized by the ability to neutralize respiratory syncytial virus (RSV). Specifically, the antibodies or antigen binding polypeptides are characterized by high affinity binding to RSV fusion glycoprotein (RSVF). Further provided are methods for their identification, isolation, generation, preparation, and use, as well as the heavy chain and light chain sequences of the antibodies provided.
Claims44
A composition comprising an antibody component, wherein:
- the antibody component consists of:
- a first antibody, or antigen binding fragment thereof, that has heavy and light chain CDRs found in antibody number 554;
- and
- a second antibody, or antigen binding fragment thereof, that has heavy and light chain CDRs found in an antibody that is selected from the group consisting of antibody numbers 843, 466, 2, 71, 112, 217, 227, 228, 249, 467, 469, 470, 832, 471, 516, 527, 532, 543, 544, 551, 571, 578, 581, 592, 615, 641, 868, and 870;
- wherein each of the first and second antibodies, or antigen binding fragments thereof, specifically binds to and neutralizes RSV F;
- and
- further wherein the composition does not include any antibodies other than the antibody component.
4 more elements
Dependencies are inferred from the claim text.