Stabilized receptor polypeptides and uses thereof
AssigneeAmgen Inc.
InventorsJeonghoon Sun, Lei-Ting Tony Tam, Mark Leo Michaels, Thomas Charles Boone, Rohini R. Deshpande, Yue-Sheng Li, Huiquan Han
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Abstract
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
Claims1
A method of inhibiting myostatin activity or activin activity in a subject in need of such treatment, a method of treating a disease in which activin is overexpressed in a subject in need of such treatment, or a method of treating a muscle wasting or metabolic or activin related disorder in a subject in need of such a treatment comprising administering a therapeutically effective amount of the composition to the subject, and wherein the composition comprises an isolated protein comprising a stabilized activin IIB receptor polypeptide (svActRIIB) that comprises a polypeptide consisting of the sequence set forth in amino acids 19 through 134 of SEQ ID NO:
- 2, except for a single amino acid substitution at position 28, and a single amino acid substitution at position 44, wherein the substitution at position 28 is selected from the group consisting of W and Y, and the substitution at position 44 is T.
Dependencies are inferred from the claim text.