US 12,630,607 B2 · PRAME TCR receptors and uses thereof

Abstract

The present invention relates to a T cell receptor (TCR) capable of binding to a PRAME peptide having the amino acid sequence SLLQHLIGL (SEQ ID NO: 1) or a portion thereof, or its HLA-A2 bound form. Also encompassed in the present invention is a nucleic acid encoding a TCR, a vector comprising the nucleic acid, and a host cell comprising the TCR, the nucleic acid sequence, or the vector. Comprised is further, a method for obtaining a TCR described herein, a pharmaceutical or diagnostic composition, and a method of detecting the presence of a cancer in a subject in vitro. Furthermore, the present invention relates to the use of a TCR, a nucleic acid and/or a vector for generating modified lymphocytes.

Claims17

Dependent claims

A T cell receptor (TCR), wherein the TCR comprises:

a) a CDR3 of the TCR alpha chain variable region comprising or consisting of the amino acid sequence of SEQ ID NO:
6, a CDR1 of the TCR alpha chain variable region comprising or consisting of the amino acid sequence of SEQ ID NO:
2, and a CDR2 of the TCR alpha chain variable region comprising or consisting of the amino acid sequence of SEQ ID NO:
4, and
b) a CDR3 of the TCR beta chain variable region comprising or consisting of the amino acid sequence of SEQ ID NO:
7, a CDR1 of the TCR beta chain variable region comprising or consisting of the amino acid sequence of SEQ ID NO:
3, and a CDR2 of the TCR beta chain variable region comprising or consisting of the amino acid sequence of SEQ ID NO:
5.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/777,977Filed 18 Nov 2020

Priority

EP 1920975718 Nov 2019

Published

US 2022/0401484 A122 Dec 2022

Granted

19 May 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification28 codes

C07K 14/70596
Receptors; Cell surface antigens; Cell surface determinants: molecules with a "CD"-designation not provided for elsewhere
A61K 38/1774
Receptors; Cell surface antigens; Cell surface determinants: immunoglobulin superfamily
A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 40/11
Characterised by the cell type used: t-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer…

PRAME TCR receptors and uses thereof

Life of this patent

PRAME TCR receptors and uses thereof

Life of this patent

Abstract

Claims17