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US 12,630,605 B2Granted
Tissue factor-targeting CAR-NK and CAR-T cell therapy
AssigneeOhio State Innovation Foundation
InventorZhiwei Hu
Life of this patent
Estimating the term…
Abstract
Disclosed are methods and compositions related to chimeric antigen receptors (CARs) that recognize Tissue Factor (TF). Specifically, disclosed are CARs that comprise fVII or a functional fragment thereof. Also disclosed are immune effector cells comprising the CARs disclosed herein.
Claims2
A natural killer (NK) cell composition comprising a chimeric antigen receptor (CAR), wherein the CAR comprises a human factor VII (fVII) light chain peptide, and wherein the CAR is encoded by a nucleic acid comprising SEQ ID NO:
- 1 or SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.