US 12,630,594 B2Granted

Allergy antigen and epitope for same

AssigneeHoyu Co., Ltd.

InventorsKayoko Matsunaga, Akiko Yagami, Naoshi Shimojo, Fumiaki Ohno

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Abstract

The present invention provides novel antigens of an allergy to fish, methods and kits for diagnosing an allergy to fish, pharmaceutical compositions comprising such an antigen, fishes, fish eggs or processed products of such fish or fish egg in which such an antigen is eliminated, fishes that deliver such fish eggs or are born from such fish egg, and a tester for determining the presence or absence of a fish antigen in an object of interest. The present invention also relates to polypeptides comprising an epitope of an antigen, kits, compositions and methods for diagnosing an allergy, comprising such a polypeptide, pharmaceutical compositions comprising such a polypeptide, and raw materials or processed products in which an antigen comprising such a polypeptide is eliminated or reduced. The present invention further relates to a tester for determining the presence or absence of an antigen in an object of interest.

Claims4

Dependent claims

A method for detecting binding between an antigen and an antibody present in a sample from a fish-allergic patient, said method comprising contacting the antigen with said antibody to detect binding, wherein said antigen is a polypeptide comprising:

(a) an epitope having the amino acid sequence selected from SEQ ID NOs:
150-152 and 154, wherein (i) the polypeptide has an amino acid sequence having at least 90% sequence identity to the amino acid sequence of any one of SEQ ID NO:
2 or (ii) the polypeptide is encoded by a nucleotide sequence having at least 90% identity to the nucleotide sequence of SEQ ID NO:
1;
(b) an epitope having the amino acid sequence selected from SEQ ID NOs:
160-162, wherein (i) the polypeptide has an amino acid sequence having at least 90% sequence identity to the amino acid sequence of any one of SEQ ID NO:
26 or (ii) the polypeptide is encoded by a nucleotide sequence having at least 90% identity to the nucleotide sequence of SEQ ID NO:
25;
or
(c) an epitope having the amino acid sequence selected from SEQ ID NOs:
175-178, wherein (i) the polypeptide has an amino acid sequence having at least 90% sequence identity to the amino acid sequence of any one of SEQ ID NO:
61 or (ii) the polypeptide is encoded by a nucleotide sequence having at least 90% identity to the nucleotide sequence of SEQ ID NO:
60;
wherein said polypeptide as defined in any one of (a), (b) and (c) specifically binds to said antibody, and wherein said antigen is immobilized to a carrier or a surface.

11 more elements

A method for detecting binding between an antigen and an antibody present in a sample from a fish-allergic patient, said method comprising detecting binding between said antigen and said antibody with a reagent capable of detecting binding between the antigen and the antibody, wherein said antigen is a polypeptide comprising:

(a) an epitope having the amino acid sequence selected from SEQ ID NOs:
150-152 and 154, wherein (i) the polypeptide has an amino acid sequence having at least 90% sequence identity to the amino acid sequence of any one of SEQ ID NO:
2 or (ii) the polypeptide is encoded by a nucleotide sequence having at least 90% identity to the nucleotide sequence of SEQ ID NO:
1;
(b) an epitope having the amino acid sequence selected from SEQ ID NOs:
160-162, wherein (i) the polypeptide has an amino acid sequence having at least 90% sequence identity to the amino acid sequence of any one of SEQ ID NO:
26 or (ii) the polypeptide is encoded by a nucleotide sequence having at least 90% identity to the nucleotide sequence of SEQ ID NO:
25;
or
(c) an epitope having the amino acid sequence selected from SEQ ID NOs:
175-178, wherein (i) the polypeptide has an amino acid sequence having at least 90% sequence identity to the amino acid sequence of any one of SEQ ID NO:
61 or (ii) the polypeptide is encoded by a nucleotide sequence having at least 90% identity to the nucleotide sequence of SEQ ID NO:
60;
wherein said polypeptide as defined in any one of (a), (b) and (c) specifically binds to said antibody.

11 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/147,789Filed 29 Dec 2022 · division
Priority: WO PCT/JP2017/01701828 Apr 2017
Published: US 2023/0295251 A121 Sep 2023
Granted: 19 May 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification25 codes

C07K 14/461
From vertebrates: from fish
A23L 17/00
Food-from-the-sea products
A23L 17/30
Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof: fish eggs, e.g. caviar; Fish-egg…
A23L 33/40
Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof: complete food formulations for specific consumer…

Family

PCT/JP2017/045832Parent of this division · filed 20 Dec 2017
US 2023/0295251 A1Pre-grant publication · published 21 Sep 2023
Application16/608,361Parent of this division
US 2020/0268877 A1Published application
US 12,630,594 B2This patent

From the US filing history. Foreign family members aren’t listed.