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US 12,630,573 B2Granted
High-affinity Cu(I) ligands and methods of use thereof
AssigneeGeorgia Tech Research Corporation
InventorsChristoph J. Fahrni, M. Thomas Morgan
Life of this patent
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Abstract
Several dimethylphosphine sulfide- and phosphine-containing compounds have been discovered that chelate copper(I) with high affinity. In certain embodiments, the compounds can be used to quantify copper(I) in complex biological systems. In another embodiment, the compounds can be used for the treatment of copper(I)-related illnesses and conditions. In still other embodiments, the compounds are ratiometric probes.
Claims8
A compound defined according to formula (V) as follows:
- wherein:
- A is any 5- or 6-membered aryl or heteroaryl ring;
- R1 is —H;
- R2 is —COOH, —COO(C1-C30 alkyl), and —CONH(C1-C30 alkyl);
- R3 is a —C1-C30 alkyl;
- or an enantiomer, polymorph or salt thereof.
3 more elements
Dependencies are inferred from the claim text.