Pyrimidinone compounds and uses thereof

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof, or a solvate, a racemic mixture, an enantiomer, a diastereomer or a tautomer thereof, wherein
• R1 is hydrogen, C1-6 alkyl, C1-6 haloalkyl, cyano-substituted C1-6 alkyl, —(C1-6 alkylene)n-C3-6 cycloalkyl, —(C1-6 alkylene)n-phenyl, —(C1-6 alkylene)n-4-6 membered heterocyclyl or —(C1-6 alkylene)n-5-6 membered heteroaryl;
• wherein the C3-6 cycloalkyl, phenyl, 4-6 membered heterocyclyl and 5-6 membered heteroaryl are each optionally substituted with one or more groups independently chosen from:
• halogen, —CN, —OH, —NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, —O(C1-6 alkyl), —O(C1-6 haloalkyl), —NH(C1-6 alkyl) and —N(C1-6 alkyl)2;
• R2 is hydrogen, halogen, —CN, —NH2, C1-6 alkyl, C1-6 haloalkyl, —O(C1-6 alkyl), —O(C1-6 haloalkyl), —NH(C1-6 alkyl) or —N(C1-6 alkyl)2;
• Z is O, NR3 or CR4R5;
• R3 is hydrogen or C1-6 alkyl;
• R4 and R5 are each independently chosen from:
• hydrogen, halogen, —CN, —OH, C1-6 alkyl, C1-6 haloalkyl, —O(C1-6 alkyl), —O(C1-6 haloalkyl) and C3-6 cycloalkyl;
• is phenyl or 5-6 membered heteroaryl, each of which is optionally substituted with one or more groups independently chosen from:
• halogen, —CN, —OH, —NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, —O(C1-6 alkyl), —O(C1-6 haloalkyl), —NH(C1-6 alkyl) and —N(C1-6 alkyl)2;
• is 5-12 membered heteroaryl, which is optionally substituted with one or more groups independently chosen from:
• halogen, —CN, —OH, oxo, —NH2, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, —O(C1-6 alkyl), —O(C1-6 haloalkyl), —NH(C1-6 alkyl), —N(C1-6 alkyl)2, —(C1-6 alkylene)n-C3-6 cycloalkyl, —(C1-6 alkylene)n-phenyl, —(C1-6 alkylene)n-4-6 membered heterocyclyl and —(C1-6 alkylene)n-5-6 membered heteroaryl;
• wherein the phenyl, C3-6 cycloalkyl, 4-6 membered heterocyclyl and 5-6 membered heteroaryl are each optionally substituted with one or more groups independently chosen from:
• halogen, —CN, —OH, —NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, —O(C1-6 alkyl), —O(C1-6 haloalkyl), —NH(C1-6 alkyl), —N(C1-6 alkyl)2 and C3-6 cycloalkyl;
• n is 0 or 1;
• and p is 0 or 1.