Endocyclic pyrimidinone compounds, and preparation methods, compositions and use thereof

A compound of Formula (I) or a pharmaceutically acceptable salt thereof,

• wherein
• n1, n2, and n3 are each independently 0, 1, or 2;
• R1 and R2 are each independently selected from the group consisting of —H, hydroxyl, cyano, halogen, alkyl, deuterated alkyl, deuterated alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, cycloalkyl, alkoxy, arylene, or heteroarylene;
• X1 and X2 are each independently selected from the group consisting of alkylene, —O—, —S—, or —NR′—,
• R′ is selected from the group consisting of —H, alkyl, deuterated alkyl, or cycloalkyl;
• Ar is arylene or heteroarylene, wherein hydrogens in the arylene or heteroarylene are each optionally substituted with one or more substituents, and the substituents are each independently selected from the group consisting of halogen, alkyl, deuteroalkyl, haloalkyl, alkoxy, deuteroalkoxy, haloalkoxy, hydroxy, hydroxyalkyl, cyano, amino, monoalkyl- or dialkyl-substituted amino, nitro, carboxy, formyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl;
• Y is selected from the group consisting of —H, halogen, alkyl, haloalkyl, haloalkoxy, cycloalkyl, alkoxy, deuterated alkyl, deuterated alkoxy, hydroxy, hydroxyalkyl, cyano, arylene, heteroarylene, —OAr′, —SAr′, —NR″—Ar′, —NR″R″, or —R′″—Ar′;
• Ar′ is aryl or heteroaryl, wherein hydrogens in the aryl or heteroaryl are optionally substituted with one or more substituents, the substituents are each independently selected from the group consisting of halogen, alkyl, haloalkyl, alkoxy, hydroxy, hydroxyalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, cyano, amino, nitro, carboxy, formyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl;
• R″ is H—, alkyl, or cycloalkyl;
• R′″ is alkylene;
• Z is O or S.