Quinazoline-2,4-diamine derivative and pharmaceutical composition for preventing or treating cancer comprising same as active ingredient

A compound, a stereoisomer thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of the following compounds:

• (3) 7-(4-(dimethylamino)-1-butyne-1-yl)-N-(1-isopropylpiperidine-4-yl)-6-methoxy-2-(piperidine-t-yl)quinazoline-4-amine;
• (6) 7-(4-(dimethylamino)-1-butyne-1-yl)-N-(2-isopropylpiperidine-4-yl)-6-methoxy-2-(pyrrolidine-1-yl)quinazoline-4-amine;
• (8) 2-(azepane-1-yl)-7-(4-(dimethylamino)-1-butyne-1-yl)-N-(1-isopropylpiperidine-4-yl)-6-methoxyquinazoline-4-amine;
• (9) 7-(4-(dimethylamino)-1-butyne-1-yl)-N-(1-isopropylpiperidine-4-yl)-6-methoxy-2-(2-azaspiro[4.4]nonane-2-yl)quinazoline-4-amine;
• (12) N-(1-isopropylpiperidine-4-yl)-6-methoxy-2-(piperidine-1-yl)-7-(4-(piperidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (14) 7-(4-(dimethylamino)-1-butyne-1-yl)-N4-(1-isopropylpiperidine-4-yl)-6-methoxy-N2,N2-dimethylquinazoline-2,4-diamine;
• (16) N-(1-isopropylpiperidine-4-yl)-6-methoxy-2-(piperidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (17) 7-(4-(dimethylamino)-1-butyne-1-yl)-N-(1-isopropylpiperidine-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepane-1-yl)quinazoline-4-amine;
• (24) N-(1-cyclopropylpiperidine-4-yl)-7-(4-(dimethylamino)-1-butyne-1-yl)-6-methoxy-2-(piperidine-1-yl)quinazoline-4-amine;
• (36) 2-(azepane-1-yl)-N-(1-isopropylpiperidine-4-yl)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (42) N-(1-isopropylpiperidine-4-yl)-6-methoxy-2-(pyrrolidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (43) N-(1-isopropylpiperidine-4-yl)-6-methoxy-7-(4-(piperidine-1-yl)-1-butyne-1-yl)-2-(pyrrolidine-1-yl)quinazoline-4-amine;
• (44) N-(1-isopropylpiperidine-4-yl)-6-methoxy-N2,N2-dimethyl-7-(4-(piperidine-1-yl)-1-butyne-1-yl)quinazoline-2,4-diamine;
• (45) N-(1-isopropylpiperidine-4-yl)-6-methoxy-2-(4-methyl1,4-diazepane-1-yl)-7-(4-(piperidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (46) ((1S,2R,5R)-3-(4-((1-isopropylpiperidine-4-yl)amino)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-2-yl)-3-azabicyclo[3.1.0]hexane-2-yl)methanol;
• (47) ((1S,2R,5R)-3-(4-((1-isopropylpiperidine-4-yl)amino)-6-methoxy-7-(4-(piperidine-1-yl)-1-butyne-1-yl)quinazoline-2-yl)-3-azabicyclo[3.1.0]hexane-2-yl)methanol;
• (48) N-(1-isopropylpiperidine-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepane-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (49) N4-(1-isopropylpiperidine-4-yl)-6-methoxy-N2,N2-dimethyl-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-2,4-diamine;
• (50) 7-(4-(dimethylamino)-1-butyne-1-yl)-N-(1-ethylpiperidine-4-yl)-6-methoxy-2-(piperidine-1-yl)quinazoline-4-amine;
• (51) N-(1-ethylpiperidine-4-yl)-6-methoxy-2-(piperidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (52) N1-(6-methoxy-2-(pyrrolidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-yl)-N2,N2-dimethylethane-1,2-diamine;
• (53) N-(1-cyclopropylpiperidine-4-yl)-6-methoxy-2-(piperidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (54) N-(1-cyclopropylpiperidine-4-yl)-6-methoxy-2-(pyrrolidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (55) N4-(1-cyclopropylpiperidine-4-yl)-6-methoxyN2,N2-dimethyl-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-2,4-diamine;
• (56) N-(1-cyclopropylpiperidine-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepane-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (57) (S)-2-(3-fluoropyrrolidine-1-yl)-N-(1-isopropylpiperidine-4-yl)-6-methoxy-7-(4-(pyrrolidinel-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (58) 2-(3,3-difluoroazetine-1-yl)-N-(1-isopropylpiperidine-4-yl)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (59) 2-(3-fluoroazetidine-1-yl)-N-(1-isopropylpiperidine-4-yl)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (60) (R)-2-(3-fluoropyrrolidine-1-yl)-N-(1-isopropylpiperidine-4-yl)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (61) N4-(2-(dimethylamino)ethyl)-6-methoxy-N2,N2-dimethyl-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-2,4-diamine;
• (62) N1-(6-methoxy-2-(4-methyl-1,4-diazepane-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-yl)-N2,N2-dimethylethane-1,2-diamine;
• (63) N4-(1-ethylpiperidine-4-yl)-6-methoxy-N2,N2-dimethyl-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-2,4-diamine;
• (64) N-(1-ethylpiperidine-4-yl)-6-methoxy-2-(pyrrolidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (65) N-(1-ethylpiperidine-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepane-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (66) (E)-N-(1-isopropylpiperidine-4-yl)-6-methoxy-2-(piperidine-1-yl)-7-(4-(piperidine-1-yl)-1-butene-1-yl)quinazoline-4-amine;
• (67) 6-methoxy-2-(piperidine-1-yl)-N-(1-propylpiperidine-4-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (68) 6-methoxy-N-(1-propylpiperidine-4-yl)-2-(pyrrolidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (69) 2-(4-((6-methoxy-2-(piperidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-yl)amino)piperidine-1-yl)ethanol;
• (70) 2-(4-((6-methoxy-2-(pyrrolidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-yl)amino)piperidine-1-yl)ethanol;
• (72) (S)—N-(1-ethylpiperidine-4-yl)-2-(3-fluoropyrrolidine-1-yl)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (73) 6-methoxy-2-(pyrrolidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)-N-(2,2,6,6-tetramethylpiperidine-4-yl)quinazoline-4-amine;
• (75) (S)—N-(1-cyclopropylpiperidine-4-yl)-2-(3-fluoropyrrolidine-1-yl)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (77) (R)—N-(1-ethylpiperidine-4-yl)-2-(3-fluoropyrrolidine-1-yl)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (78) (S)—N-(1-ethylpiperidine-4-yl)-7-(4-(3-fluoropyrrolidine-1-yl)-1-butyne-1-yl)-6-methoxy-2-(pyrrolidine-1-yl)quinazoline-4-amine;
• (82) tert-butyl 2-((4-((1-isopropylpiperidine-4-yl)amino)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-2-yl)(methyl)amino)acetate;
• (83) 6-methoxy-N2,N2-dimethyl-N4-(1-propylpiperidine-4-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-2,4-diamine;
• (84) (R)-2-(3-fluoropyrrolidine-1-yl)-6-methoxy-N-(1-propylpiperidine-4-yl)-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-amine;
• (85) (E)-N-(1-isopropylpiperidine-4-yl)-6-methoxy-2-(pyrrolidine-1-yl)-7-(4-(pyrrolidine-1-yl)-1-butene-1-yl)quinazoline-4-amine;
• (87) 2-(4-((2-(dimethylamino)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-yl)amino)piperidine-1-yl)ethanol;
• and
• (89) (R)-2-(4-((2-(3-(fluoropyrrolidine-1-yl)-6-methoxy-7-(4-(pyrrolidine-1-yl)-1-butyne-1-yl)quinazoline-4-yl)amino)piperidine-1-yl)ethanol.