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US 12,630,523 B2Granted
Isoquinoline derivatives for use as antiviral and antitumour agents
AssigneesRdp Pharma AG, Pags Co., Ltd.
InventorsLutz Weber, Christian Kühne
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds of formula (I), especially the use thereof as degraders of Human Papilloma Virus E7 proteins: formula (I).
Claims11
A compound selected from the group consisting of
- (3R,4R)-N-[3-(4-methylpiperazin-1-yl) phenyl]-2-[(1-methylpiperidin-4-yl) methyl]-1-oxo-3-[4-(trifluoromethyl) phenyl]-1,2,3,4-tetrahydroisoquinoline-4-carboxamide),
- (3S,4S)-N-[3-(4-methylpiperazin-1-yl) phenyl]-2-[(1-methylpiperidin-4-yl) methyl]-1-oxo-3-[4-(trifluoromethyl) phenyl]-1,2,3,4-tetrahydroisoquinoline-4-carboxamide),
- (3R,4R)-N-[3-(4-methylpiperazin-1-yl) phenyl]-2-[(4-methylphenyl) methyl]-1-oxo-3-[4-(trifluoromethyl) phenyl]-1,2,3,4-tetrahydroisoquinoline-4-carboxamide),
- (3S,4S)-N-[3-(4-methylpiperazin-1-yl) phenyl]-2-[(4-methylphenyl) methyl]-1-oxo-3-[4-(trifluoromethyl) phenyl]-1,2,3,4-tetrahydroisoquinoline-4-carboxamide),
- (3R,4R)-2-(4-methylbenzyl)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-3-(6-(trifluoromethyl) pyridin-3-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3R,4R)-7-methoxy-2-(4-methylbenzyl)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3R,4R)-7-acetamido-2-(4-methylbenzyl)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3R,4R)-6,7-dimethoxy-2-(4-methylbenzyl)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3R,4R)-2-(4-methylbenzyl)-N-(4-(4-methylpiperazin-1-yl) phenyl)-1-oxo-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3R,4R)-2-(4-methylbenzyl)-N-(3-morpholinophenyl)-1-oxo-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3R,4R)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-2-(pyridin-4-ylmethyl)-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3R,4R)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-2-(pyridin-3-ylmethyl)-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3S,4S)-2-(4-methylbenzyl)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-3-(6-(trifluoromethyl) pyridin-3-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3S,4S)-7-methoxy-2-(4-methylbenzyl)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3S,4S)-7-acetamido-2-(4-methylbenzyl)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3S,4S)-6,7-dimethoxy-2-(4-methylbenzyl)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3S,4S)-2-(4-methylbenzyl)-N-(4-(4-methylpiperazin-1-yl) phenyl)-1-oxo-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3S,4S)-2-(4-methylbenzyl)-N-(3-morpholinophenyl)-1-oxo-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide,
- (3S,4S)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-2-(pyridin-4-ylmethyl)-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide, and
- (3S,4S)-N-(3-(4-methylpiperazin-1-yl) phenyl)-1-oxo-2-(pyridin-3-ylmethyl)-3-(4-(trifluoromethyl) phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide.
17 more elements
Dependencies are inferred from the claim text.