Arylamides and methods of use thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• A is selected from
• wherein * marks the point of attachment to Y and ** marks the point of attachment to —C(O)—;
• Z1 and Z2 are each independently CH, S or N, wherein at least one of Z1 and Z2 is N or S;
• Y is —O—;
• E is C3-9-cycloalkyl, C6-10-aryl, 3-10 membered heteroaryl, or a 3-9 membered heterocycloalkyl, each of which is optionally substituted with one, two, three, four, or five occurrences of R5;
• V is —C(O)—O—R7;
• R1 is
• wherein
• Ra is C1-6 alkyl,
• Rb is C1-6 alkyl,
• Rc is C1-6 alkyl or C6-10 aryl, or
• any two of Ra, Rb, and Rc, taken together with the atoms to which they are attached, form a C3-9 cycloalkyl ring;
• each R2 is independently halo, C1-6 alkyl, haloC1-6 alkyl, —O—C1-6 alkyl, —O-halo C1-6 alkyl, C3-9-cycloalkyl or 3-10 membered heteroaryl;
• R3 is H or alkyl;
• each R5 is independently halo, C1-6 alkyl, C1-6 haloalkyl, —O— C1-6alkyl, —O—C1-6haloalkyl, and —S— C1-6haloalkyl;
• R7 is hydrogen, C1-6-alkyl, C6-10-aryl, or benzyl;
• and
• m is 0, 1, or 2.