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US 12,630,499 B2Granted
Benzaldehyde oximes and method for producing same
AssigneeBayer Aktiengesellschaft
InventorAndreas Rembiak
Life of this patent
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Abstract
The present invention relates to a method for preparing benzaldehyde oximes of the general formula (I) and to the use thereof as important precursors for the synthesis of agrochemical and pharmaceutical active substances
Claims14
A method for preparing a compound of formula (I)
- in which formula (I) includes both (E) and (Z) isomers, and wherein
- X2 is H, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 fluoroxyalkyl, C1-C4 alkoxy, fluorine, or CN;
- X3 is H, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 fluoroxyalkyl, C1-C4 alkoxy, fluorine, chlorine, or CN;
- X4 is H, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 fluoroxyalkyl, C1-C4 alkoxy, fluorine, or CN;
- X5 is H, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 fluoroxyalkyl, C1-C4 alkoxy, fluorine, chlorine, or CN;
- and
- X6 is H, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 fluoroxyalkyl, C1-C4 alkoxy, fluorine, or CN;
- and wherein the compounds of formula (II)
- in which the radicals are as defined above,
- are in a first reaction step reacted in the presence of isopropylmagnesium chloride and dimethylformamide (DMF) to form corresponding adducts of formula (III),
- which in a second reaction step with addition of acid and hydroxylamine react further to aldehydes of formula (IV)
- in which the radicals are as defined above,
- and undergoes continuous reaction to form the compounds of the formula (I).
10 more elements
Dependencies are inferred from the claim text.