Arylamides and methods of use thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• A is
• wherein * marks the point of attachment to Y and ** marks the point of attachment to-C(O)—;
• Z1, Z4, and Z5 are each independently CR6;
• Z2 and Z3 are each independently CR2;
• Y is —O—;
• E is C2-6-alkynyl, C3-9-cycloalkyl, C4-9-cycloalkenyl, C6-10-aryl, 3-10 membered heteroaryl, or 3-9 membered heterocycloalkyl, each of which is optionally substituted with one, two, three, four, or five occurrences of R5;
• V is —C(O)—O—R7;
• R1 is
• wherein
• Ra is C1-6 alkyl,
• Rb is C1-6 alkyl, or haloC1-6 alkyl, wherein each alkyl is optionally substituted with one, two, three, four, or five occurrences of R9;
• Rc is C1-6 alkyl, haloC1-6 alkyl, or C6-10 aryl each of which is optionally and independently substituted with one, two, three, four, or five occurrences of R10;
• Ra and Rc, taken together with the atoms to which they are attached, form a C3-8 cycloalkyl, or a C3-8 heterocycloalkyl ring, or
• Ra, Rb, and Rc are taken together with the atoms to which they are attached to form a bridged C5-9 cycloalkyl;
• each R2 is independently hydrogen, halo, —CN, —OH, —NH2, —N—(C1-6 alkyl)2, C1-6 alkyl, haloC1-6 alkyl, —O—C1-6 alkyl, —O-haloC1-6 alkyl, —O—C2-6 alkenyl, or 3-10 membered heteroaryl;
• R3 is hydrogen or C1-6 alkyl;
• R4 is hydrogen or C1-4 alkyl;
• each R5 is independently halo, —CN, —NO2, C1-6 alkyl, hydroxyC1-6 alkyl, C1-6 haloalkyl, C3-9-cycloalkyl, C2-6-alkenyl, —O—C1-6 alkyl, —O—C1-6 haloalkyl, —C(O)—O—C1-6 alkyl, —SF5, —S—C1-6 alkyl, —S—C1-6 haloalkyl, —S(O)2—C1-6 alkyl, —S(O)2—C1-6 haloalkyl, or 3-10 membered heteroaryl;
• or two R5 moieties, taken together with the atoms to which they are attached, form a 3-8 membered heterocycloalkyl ring, wherein each heterocycloalkyl is substituted with one, two, or three occurrences of R8;
• each R6 is independently hydrogen, halo, or C1-6-alkyl;
• R7 is hydrogen, C1-6-alkyl, C6-10 aryl, or benzyl;
• each R8 is independently hydrogen, halo or C1-6-alkyl;
• each R9 is independently hydrogen, halo, C1-6-alkyl, haloC1-6-alkyl, or C3-9-cycloalkyl;
• and
• each R10 is independently hydrogen, halo, —CN, —OH, C1-6-alkyl, haloC1-6 alkyl, —O—C1-6 alkyl, —O-haloC1-6 alkyl, —O—C2-6-alkenyl, C1-4-alkylaryl, —O—C1-6-alkylaryl, —O—C1-6 alkyl-O—C1-6 alkyl, —C(O)OC1-6 alkyl, —S—C1-6 alkyl, —N═(NH2)2, C6-10 aryl, or 3-10 membered heteroaryl.