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US 12,629,953 B2Granted
Methods and composition for the fabrication of 3D perfusable networks
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsJulien G. Roth, Sungchul Shin, Alexis J. Seymour, Sarah C. Heilshorn
Life of this patent
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Abstract
Methods and compositions for fabricating 3D perfusable networks are described. The methods utilize (1) printable compositions comprising gelatin microgels or Pluronic F-127, and crosslinking initiators; and (2) support materials comprising crosslinkable polymers and gelling agents. In some embodiments, the support material further comprises a co-initiator.
Claims19
A method for fabricating a 3D perfusable network, the method comprising:
- (i) contacting a support material with an injection means, wherein the support material comprises a crosslinkable monomer or polymer and a viscosity modifier, in the absence of a crosslinking initiator;
- (ii) injecting a printable composition into the support material using the injection means;
- wherein the printable composition comprises a sacrificial ink, and a crosslinking initiator;
- (iii) moving the injection means in a desired 3D shape wherein the injection means is continuously injecting the printable composition into the support material, and
- (iv) altering the temperature of the support material to melt the sacrificial ink.
2 more elements
Dependencies are inferred from the claim text.