Oligonucleotide encoded chemical libraries

A plurality of bead complexes comprising a first bead complex and a second bead complex, the first bead complex comprising:

• a first bead;
• a first plurality of same compounds directly bound to the first bead at a first position via a first cleavable linker;
• and
• directly bound to the first bead at a second position different from the first position, in a sequential order:
• a linker;
• a first primer directly bound to the first linker;
• a first encoding region comprising a first single-stranded DNA barcode, wherein the first single-stranded DNA barcode is directly bound to the first primer;
• and
• a first nucleic acid capturing group comprising a first poly-T sequence, the first nucleic acid capturing group being single-stranded and directly bound to the first single-stranded DNA barcode, wherein:
• the first encoding region encodes a structure of each first same compound of the first plurality of same compounds or synthetic steps used to make the each first same compound;
• and the second bead complex comprising:
• a second bead;
• a second plurality of second same compounds directly bound to the second bead at a third position via a second cleavable linker;
• and
• directly bound to the second bead at a fourth position different from the third position, in a sequential order:
• a second linker;
• a second primer directly bound to the second linker;
• a second encoding region comprising a second single-stranded DNA barcode, wherein the second single-stranded DNA barcode is directly bound to the first primer;
• and
• a second nucleic acid capturing group comprising a second poly-T sequence, the second nucleic acid capturing group being single-stranded and directly bound to the second single-stranded DNA barcode, wherein:
• the second encoding region encodes a structure of each second same compound of the second plurality of same compounds or synthetic steps used to make the each second same compound, the second plurality of second same compounds are different from the first plurality of first same compounds, and the second single-stranded DNA barcode is different from the first single-stranded DNA barcode.