Buffer management for bioprocessing system

A buffer management system comprising:

• a supply of concentrated buffer solution;
• a dilution skid, the dilution skid including a single use manifold and a control unit, the single use manifold in fluid communication with the supply of concentrated buffer solution, the manifold adapted to be placed in fluid communication with a source of water for injection (WFI), the control unit configured to operate the dilution skid to selectively mix the supply of concentrated buffer solution with an amount of WFI from the source of WFI in the single use manifold to produce a diluted buffer solution;
• a biocontainer assembly, the biocontainer assembly including a biocontainer bag, a fill level sensor, and a shelf, the biocontainer bag defining a storage volume, the biocontainer bag in fluid communication with the manifold of the dilution skid for storing diluted buffer solution therein, the fill level sensor configured to generate a fill level signal indicative of a volume of material within the storage volume of the biocontainer bag, and the fill level sensor in communication with the control unit of the dilution skid to transmit the fill level signal thereto, wherein the shelf has a support surface configured to support the biocontainer bag and disposed at an oblique angle with respect to a horizontal axis, and wherein the fill level sensor comprises a capacitive fill level sensor mounted to the support surface;
• wherein the control unit is configured to divert the diluted buffer solution away from the storage volume of the biocontainer bag if the buffer solution being produced is outside of a predetermined tolerance range of a given specification for a desired buffer, to fill the storage volume of the biocontainer with the diluted buffer solution when the buffer solution being produced is within the predetermined tolerance of the buffer recipe, to stop production of the diluted buffer solution once a predetermined fill volume of diluted buffer solution is in the storage volume of the biocontainer bag based upon the fill level signal received from the fill level sensor, and to maintain a predetermined minimum volume of diluted buffer solution in the storage volume of the biocontainer bag based upon the fill level signal received from the fill level sensor by operating, once the fill level signal indicates the minimum volume has been reached, the dilution skid to selectively mix the supply of concentrated buffer solution with an amount of WFI from the source of WFI in the single use manifold to produce an additional amount of diluted buffer solution to bring the diluted buffer solution in the storage volume of the biocontainer bag above a predetermined operational volume based upon the fill level signal received from the fill level sensor.