Hyaluronic acid-based hydrogel using peptide crosslinking agent, and method for producing same

A hyaluronic acid-based hydrogel comprising a peptide cross-linking agent comprising 3-5 of amino acids and a hyaluronic acid or a salt thereof,

• wherein the peptide cross-linking agent has any one structure of the following Chemical formulas 2 to 4,
• X1—X2—X3—NH2 [Chemical formula 2]
• Y1—Y2—Y3—Y4—NH2 [Chemical formula 3]
• Z1—Z2—Z3—Z4—Z5—NH2 [Chemical formula 4]
• in the formula,
• X3, Y4 and Z5 are each independently lysine (Lys),
• X1, X2, Y1, Y2, Y3, Z1, Z2, Z3 and Z4 are each independently selected from the group consisting of glutamine (Gln), asparagine (Asn), serine (Ser), cysteine (Cys), beta alanine β-Ala), alanine (Ala), glycine (Gly), leucine (Leu), isoleucine (Ile), valine (Val), threonine (Thr), methionine (Met), proline (Pro), phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp),
• in the Chemical formulas 2 to 4, lysine of X3, Y4 and Z5 comprises an amide group (—CONH2) instead of a carboxyl group (—COOH), and
• wherein the NH2 group of the Chemical formulas 2 to 4 is the amino group of the amide group (—CONH2).