Vascular embolic system
Assignee3-D Matrix, Ltd.
InventorsSatoru Kobayashi, Kentaro Takamura
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Abstract
Systems and methods of blocking a biological vessel are provided. The systems and methods may comprise introducing to the vessel an amphiphilic peptide. The peptide may comprise at least thirteen amino acids that may alternate between a hydrophobic amino acid and a hydrophilic amino acid. The peptide may form a beta-sheet spontaneously in an aqueous solution in the presence of a cation.
Claims9
A method for reducing or eliminating cancerous cells in a subject by forming at least a partial blockage, lodging, occlusion, or embolism in a targeted biological vessel in which blood is flowing, to deprive a tumor in the subject of blood supply, or for treating patent ductus arteriosus (PDA) or major aortopulmonary collateral artery (MAPCA), in a human subject, the method comprising:
- administering a solution comprising an amphiphilic self-assembling peptide having the amino acid sequence IEIKIEIKIEIKI (SEQ ID NO:8) in an effective amount and in an effective concentration to form a hydrogel under physiological conditions to provide at least partial blockage of the biological vessel effecting embolization or cell necrosis therein,
- wherein the concentration effective to provide at least partial blockage of the biological vessel comprises a concentration within the range of 0.1 weight per volume (w/v) percent to 3 w/v percent peptide.
Dependencies are inferred from the claim text.