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US 12,629,410 B2Granted
Multi-antigenic peptide mimics of gonococcal lipo-oligosaccharide (LOS) epitopes
AssigneeUniversity of Massachusetts
InventorsPeter A. Rice, Michael W. Pennington, Sunita Gulati, Jutamas Shaughnessy, Sanjay Ram
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Abstract
In some aspects, the disclosure relates to compositions of peptide mimics useful in the treatment of Neisseria gonorrhoeae (N. gonorrhoeae). In some embodiments, the peptide mimics are multi-antigenic molecules of a conserved gonococcal lipo-oligosaccharaide (LOS) epitope. In some aspects, the disclosure relates to methods of making peptide mimics for the treatment of N. gonorrhoeae. In some aspects, the disclosure relates to methods of using peptide mimics for the treatment of N. gonorrhoeae.
Claims2
A compound of Formula (I-c):
- or a salt or polymorph thereof, wherein:
- A2, A3, A5, and A6, are each independently glycine, proline, or cysteine
- A4 is *-Ile-Pro-Val-Leu-Asp-Glu-Asn-Gly-Leu-Phe-Ala-Pro- (SEQ ID NO:
- 2), wherein * indicates attachment to A5;
- and
- A7 is *-(C═O)—CH2—;
- wherein * indicates attachment to A6.
4 more elements
Dependencies are inferred from the claim text.