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US 12,629,408 B2Granted
Peptides with anti-tumor activity
AssigneeUniversita' Degli Studi Di Padova
InventorsAndrea Rasola, Francesco Ciscato, Paolo Bernardi
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Abstract
The invention concerns an isolated peptide and variants thereof, and therapeutic uses thereof. In particular, such peptides have anti-tumor activity with high selectivity, efficacy and low toxicity. Pharmaceutical compositions comprising the peptides of the invention are also described.
Claims11
An isolated peptide having a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:8, SEQ ID NO:9, and SEQ ID NO:
- 10, wherein said peptide allows:
- a) specific release of an active portion of a hexokinase 2 (HK2) protein in the proximity of neoplastic cells;
- b) penetration through a cell membrane;
- and/or
- c) rapid killing of tumor cells.
2 more elements
Dependencies are inferred from the claim text.