Method of treating covid-19 infection using superparamagnetic iron oxide nanoparticle

A method of treating a COVID-19 infection, comprising:

• administering to a subject in need thereof an effective amount of a composition,
• wherein the composition comprises:
• silica nanoparticles;
• superparamagnetic iron oxide nanoparticles (SPIONs), wherein the SPIONs consist of Fe3O4;
• 0.3-0.8 wt % chitosan;
• cisplatin;
• 3-6 wt % ribavirin;
• and
• 0.1-0.6 wt % angiotensin-converting enzyme 2 (ACE-2),
• where wt % is based on the total weight of the composition,
• wherein the SPIONs and ACE-2 are dispersed on an outer surface of the silica nanoparticles,
• wherein the chitosan wraps around at least 20% of the surface area of the silica nanoparticles,
• wherein the cisplatin and ribavirin are in pores of the silica nanoparticles,
• wherein the composition is in the form of particles that are monodisperse, are spherical, and have an average diameter of 70-100 nm,
• wherein the composition has a BET surface area of 75-100 m2/g,
• wherein 72 hours after administering the composition, the composition releases 20-30% of the cisplatin at a pH of 5-6,
• wherein 72 hours after administering the composition, the composition releases 10-20% of the ribavirin at a pH of 5-6,
• wherein the chitosan only wraps around an external pore wall of the silica nanoparticles and does not block the pores of the silica nanoparticles, and
• wherein 30-60% of the surface area of the silica nanoparticles is covered with the chitosan, SPIONs, and ACE-2.