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US 12,629,382 B2Granted
Therapy
AssigneeVestlandets Innovasjonsselskap AS
InventorsHans-René Bjørsvik, Per Øyvind Enger, Davide Cirillo, Shahin Sarowar
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AssigneeVestlandets Innovasjonsselskap AS
InventorsHans-René Bjørsvik, Per Øyvind Enger, Davide Cirillo, Shahin Sarowar
Estimating the term…
The invention addresses radioresistance in cancer treatment involving radiotherapy and, in particular, limitations associated with the use of the drug sulfasalazine. Specifically, it provides a series of compounds for use as radiosensitizers in the treatment of cancers such as glioblastomas which are lethal and inherently resistant to radiotherapy. In one embodiment, the invention provides compounds of general formula (I), their stereoisomers and pharmaceutically acceptable salts for use as radiosensitizers in the treatment of cancer: wherein ring A is selected from optionally substituted phenyl, biphenyl and fluorenyl; each X is independently selected from: —C1-6 alkyl (preferably C1-3 alkyl, e.g. —CH3), —O—C1-6 alkyl (preferably —O—C1-3 alkyl, e.g. —OCH3), —S—C1-6 alkyl (preferably —S—C1-3 alkyl, e.g. —SCH3), —OH, —SH, —CO2R1 (where R1 is H or C1-6 alkyl, preferably C1-3 alkyl, e.g. —CH3), —SO2—C1-6 alkyl (preferably —SO2—C1-3 alkyl, e.g. —SO2—CH3), —SO2—NR2R3 (where R2 is H and R3 is optionally substituted phenyl), —NR4R5 (wherein R4 and R5 are independently selected from H, C1-6 alkyl (preferably C1-3 alkyl, e.g. —CH3), and —CO—C1-6 alkyl (preferably —CO—C1-3 alkyl, e.g. —CO—CH3), halogen (e.g. F, Cl or Br), and optionally substituted tetrazolyl; n is an integer from 0 to 5, preferably 0 to 2, e.g. 1 or 2; and denotes an E or Z double bond.
A method of treating cancer, said method comprising the step of administering to a patient in need thereof a pharmaceutically effective amount of a compound of general formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof, in combination with radiotherapy:
A method of treating cancer, said method comprising the step of administering to a patient in need thereof a pharmaceutically effective amount of a compound, a stereoisomer, or a pharmaceutically acceptable salt thereof, in combination with radiotherapy, wherein said compound is selected from the following and their stereoisomers, and pharmaceutically acceptable salts:
A method of treating cancer, said method comprising the step of administering to a patient in need thereof a pharmaceutically effective amount of a compound of general formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof, in combination with radiotherapy:
Dependencies are inferred from the claim text.