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US 12,629,344 B2Granted
TTS-formulation with THC
AssigneeLTS Lohmann Therapie-Systeme AG
InventorsEva-Marie Prinz, Marco Emgenbroich, Birgit Braun, Peter Bohnenkämper
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Abstract
Disclosed is a transdermal therapeutic system comprising an active agent impermeable backing layer, at least one adhesive layer comprising at least 70% by weight of at least one polysiloxane polymer, at least one tetrahydrocannabinol (THC) and at least one solubilizer, and optionally a protective layer for removal before use, a method for its preparation and its use as a medicament.
Claims15
A transdermal therapeutic system comprising
- i) an active agent impermeable backing layer, ii) at least one adhesive layer comprising at least 70% by weight of at least two polysiloxane polymer, at least one tetrahydrocannabinol (THC) and at least one solubilizer, and optionally iii) a protective layer for removal before use, wherein the at least one solubilizer is selected from the group consisting of polyvinylpyrrolidone, pentanoic acid, capric acid, caprylic acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, linoleic acid, lignoceric acid, isoverlic acid, neoheptonic acid, neonanonic acid, isostearic acid, pentanoic acid, hexanoic acid, ricinoleic acid, octanoic acid, nonanoic acid, decanoic acid, lauric acid, oleic acid, arachidonic acid, galloleic acid, erucic acid, polyethylene glycol monolaureate, PEG-6 mono- and diesters of oleic acid, polyethylene glycol dodecyl ether/polyoxyethylene(4)lauryl ether, a polyvinylcaprolactam-/polyvinylacetate-/polyethyleneglycol-copolymer, wherein the polysiloxane polymers are amine-resistant, and wherein the adhesive layer comprises a mixture of a high-tack and a medium or low-tack silicone polymer.
A transdermal therapeutic system comprising
- i) an active agent impermeable backing layer, ii) at least one adhesive layer comprising at least 70% by weight of at least two polysiloxane polymer, at least one tetrahydrocannabinol (THC) and at least one solubilizer, and iii) a protective layer for removal before use, wherein the at least one solubilizer is selected from the group consisting of polyvinylpyrrolidone, pentanoic acid, capric acid, caprylic acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, linoleic acid, lignoceric acid, isoverlic acid, neoheptonic acid, neonanonic acid, isostearic acid, pentanoic acid, hexanoic acid, ricinoleic acid, octanoic acid, nonanoic acid, decanoic acid, lauric acid, oleic acid, arachidonic acid, galloleic acid, erucic acid, polyethylene glycol monolaureate, PEG-6 mono- and diesters of oleic acid, polyethylene glycol dodecyl ether/polyoxyethylene(4)lauryl ether, a polyvinylcaprolactam-/polyvinylacetate-/polyethyleneglycol-copolymer, wherein the polysiloxane polymers are amine-resistant, and wherein the adhesive layer comprises a mixture of a high-tack and a medium or low-tack silicone polymer.
Dependencies are inferred from the claim text.