Medical device inserters and processes of inserting and using medical devices

A glucose monitoring assembly, comprising:

• (1) an inserter, comprising:
• an inserter housing slidably coupled with a sheath, wherein the sheath comprises a longitudinal slot;
• a carrier comprising a laterally-extending protrusion configured to engage the longitudinal slot;
• and
• a sharp configured to insert a portion of a transcutaneous glucose sensor into a subject;
• and
• (2) an on body electronics unit, comprising:
• an on body electronics unit housing;
• the transcutaneous glucose sensor, comprising:
• a proximal portion configured to couple with on body electronics above the subject's skin;
• and
• a distal portion configured to be positioned in a subcutaneous space in contact with the subject's bodily fluid and to generate electrical signals indicative of a glucose level of the subject, wherein the distal portion comprises a glucose-responsive enzyme;
• and
• the on body electronics comprising a processor, memory, a power supply, and wireless communication circuitry, wherein the on body electronics is disposed in the on body electronics unit housing, and
• wherein the inserter is configured to:
• advance the on body electronics unit and the sharp from a proximal position entirely within the inserter to a distal position, such that the sharp pierces the skin of the subject and the on body electronics unit housing is secured to the skin of the subject in the distal position,
• automatically retract the sharp from the distal position to a retracted position entirely within the inserter, and
• wherein the laterally-extending protrusion is configured to traverse the longitudinal slot in a linear and distal direction when the on body electronics unit and the sharp are advanced from the proximal position to the distal position.