Detecting and correcting for interference in an analyte monitoring system

A glucose monitoring system comprising:

• a glucose sensor comprising:
• a first indicator element including a first analyte indicator and a first interferent indicator;
• a second indicator element including a second analyte indicator and a second inteferent indicator;
• first and second sensing areas;
• first measurement electronics in the first sensing area, wherein the first measurement electronics is configured to, for each of multiple instances of time over a 365 day period, generate a first sensing area glucose measurement and a first sensing area degradation measurement, the first measurement electronics is configured to use the first analyte indicator to generate the first sensing area glucose measurement and the first interferent indicator to generate the first sensing area degradation measurement, the first sensing area glucose measurement is indicative of an amount or concentration of glucose in interstitial fluid in proximity to the first indicator element, the first sensing area glucose measurement varies in accordance with at least degradation of the first interferent indicator, which corresponds to degradation of the first analyte indicator, and the first sensing area degradation measurement is indicative of degradation of the first interferent indicator;
• and
• second measurement electronics in the second sensing area, wherein the first measurement electronics is configured to, for each of the multiple instances of time over the 365 day period, generate a second sensing area glucose measurement and a second sensing area degradation measurement, the second measurement electronics is configured to use the second analyte indicator to generate the second sensing area glucose measurement and the second interferent indicator to generate the second sensing area degradation measurement, the second sensing area glucose measurement is indicative of an amount or concentration of glucose in interstitial fluid in proximity to the second indicator element, the second sensing area glucose measurement varies in accordance with at least degradation of the second interferent indicator, which corresponds to degradation of the second analyte indicator, and the second sensing area degradation measurement is indicative of degradation of the second interferent indicator;
• a controller configured to, for each of multiple instances of time over a 365 day period:
• calculate a first sensing area glucose concentration using at least the first sensing area glucose measurement;
• calculate a second sensing area glucose concentration using at least the second sensing area glucose measurement;
• calculate a first weight for the first sensing area glucose concentration using at least the first sensing area degradation measurement;
• calculate a second weight for the second sensing area glucose concentration using at least the second sensing area degradation measurement;
• and
• calculate a combined glucose concentration as a weighted average of at least the first and second sensing area glucose concentrations using at least the first and second weights;
• wherein the glucose monitoring system is configured to display the calculated combined glucose concentration;
• wherein the combined glucose concentrations for the multiple instances of time over the 365 day period would have (a) an overall mean average relative difference (MARD) versus self-monitoring blood glucose (SMBG) values of less than or equal to 10.4% and a 40/40% concurrence of greater than or equal to 98.5% if the calculation of the sensing area glucose concentrations were calibrated using one SMBG value on every seventh day of the 365 day period or (b) an overall MARD versus SMBG values of less than or equal to 10.3% and a concurrence of greater than or equal to 98.8% if the calculation of the sensing area glucose concentrations were calibrated using two SMBG values on every 14th day of the 365 day period.