Nutritional composition having lipophilic compounds with improved solubility and bioavailability
AssigneeAbbott Laboratories
InventorsPaul Johns, Mustafa Vurma, Daniel Albrecht, Stephen DeMichele, Gary Katz, Todime Reddy
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Abstract
Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.
Claims21
A nutritional composition comprising an emulsion of an aqueous phase and a lipid phase:
- wherein the lipid phase includes triglycerides;
- wherein the aqueous phase includes a carbohydrate and assemblies comprising:
- a vitamin comprising one or more of vitamins A, D, E, or K;
- a hydrophobic protein;
- a phospholipid;
- and
- a monoglyceride and diglyceride oil (MDG oil);
- and
- wherein at least 5% of the assemblies remains in the aqueous phase after centrifugation at 31,000×g for one hour at 20° C.
A method of preparing a nutritional composition, the method comprising:
- (a) mixing a vitamin comprising one or more of vitamins A, D, E, and K;
- a phospholipid;
- and a monoglyceride and diglyceride oil (MDG oil) to form a premix, the premix containing less than 20% by weight triglycerides;
- (b) combining the premix with a protein-in-water slurry containing one or more hydrophobic proteins to form water-soluble assemblies comprising the vitamin, the phospholipid, the MDG oil, and the one or more hydrophobic proteins;
- (c) combining the result of step (b) with one or more additional nutritional components, wherein at least one of the one or more additional nutritional components comprises triglycerides;
- and
- (d) emulsifying to produce a liquid nutritional composition having an aqueous phase and a lipid phase, in which at least a portion of the assemblies remain in the aqueous phase.
Dependencies are inferred from the claim text.