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US 12,628,854 B2Granted
Delayed release softgel capsules in higher pH environment
AssigneeR.P. Scherer Technologies, LLC
InventorsKarunakar Sukuru, Qi Fang, Haitao Li
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Abstract
Disclosed in certain embodiments is a delayed release softgel capsules comprise a fill material that is encapsulated in a pH dependent shell composition, the pH dependent shell composition including pectin and gellan gum. Also disclosed are methods of preparing any of the delayed release softgel capsules described herein and methods of use thereof.
Claims13
A delayed release softgel capsule comprising:
- (a) a fill material;
- and
- (b) a shell composition,
- wherein the fill material comprises at least one active agent, and
- wherein the shell composition comprises gelatin and a pH dependent polymer comprising pectin and gellan gum, wherein a ratio of the pectin to gellan gum is from about 10:1 to about 24:1, and about 0.01 wt % to about 2 wt % of dextrose, wherein the shell composition does not rupture at a pH of 4 at 15 minutes, 30 minutes, 45 minutes or 60 minutes when measured with a USP Apparatus II with paddles at 50 RPM, 900 ml 0.1N HCL acidic media adjusted to pH with phosphate buffer.
2 more elements
Dependencies are inferred from the claim text.