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US 12,626,899 B2Granted
Mass spectrometer and method
AssigneeTruemass Ltd
InventorJohn Brian Hoyes
Life of this patent
Estimating the term…
Abstract
A charge detection mass spectrometer, CDMS, is described. The CDMS 4, comprises: an electrostatic sector field ion trap 40 and an inductive charge detector 400; wherein the electrostatic sector field ion trap 40 is configured to define, at least in part, an ion path via the inductive charge detector 400. A method is also described.
Claims14
A charge detection mass spectrometer (CDMS), comprising:
- an electrostatic sector field ion trap;
- an inductive charge detector;
- and
- a set of electrostatic focus lenses including a first focus lens;
- wherein the electrostatic sector field ion trap is configured to define, at least in part, an ion path via the inductive charge detector;
- wherein a mass m of an ion moving around the ion path is determined by determining a mass to charge m/z and a charge z of the ion using signals induced by the ion in the inductive charge detector;
- wherein the electrostatic sector field ion trap comprises a set of electrostatic sectors, including a first electrostatic sector and a second electrostatic sector, wherein the ion moves with a constant speed around the ion path;
- wherein the first electrostatic sector and the second electrostatic sector are spherical electrostatic sectors;
- wherein the first electrostatic sector and the second electrostatic sector are mutually opposed;
- wherein the ion path defined by the electrostatic sector field ion trap includes a crossover;
- wherein the set of electrostatic focus lenses, including the first focus lens, is arranged to constrain, at least in part, the ion path in a first dimension;
- wherein the first dimension is orthogonal to a direction of the ion path via the inductive charge detector;
- and
- wherein the first focus lens comprises and/or is a cylinder lens, an einzel lens and/or a plate lens disposed across the crossover in the ion path.
11 more elements
A method of determining a mass of an ion, the method comprising:
- moving an ion with a constant speed along an ion path having a crossover by an electrostatic sector field ion trap comprising a plurality of electrostatic sectors including a first spherical electrostatic sector and a second spherical electrostatic sector disposed in opposition to the first spherical electrostatic sector, wherein the ion path is constrained in a first dimension orthogonal to a direction of the ion path via an inductive charge detector and a plurality of electrostatic focus lenses including a first focus lens disposed across the crossover in the ion path, the first focus lens comprising a cylinder lens, an einzel lens, or a plate lens, and wherein the moving ion induces signals in the inductive charge detector;
- and
- determining the mass of the ion by determining a mass-to-charge ratio from the induced signals and a charge of the ion from the induced signals.
Dependencies are inferred from the claim text.