System and method for the detection of gamma radiation from a radioactive analyte and providing real time administration feedback
AssigneeLucerno Dynamics, LLC
InventorsJoshua G. Knowland, Charles W. Scarantino, Ronald K. Lattanze, Steve Perrin
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Abstract
A system and method for the measurement of radiation emitted from an in-vivo administered radioactive analyte. Gamma radiation sensors may be used to determine the proper or improper administration of a radioactive analyte, and provide real time feedback to an autoinjector or other administration device or person. The feedback may include identification of an infiltration event and/or a likelihood that an infiltration event resulted in a radiation dose to a patient above a certain value, among other things.
Claims20
A system for providing real-time feedback to an auto-injection system during administration of a radioactive analyte that decays in vivo, the system comprising:
- at least one ex vivo gamma radiation measurement sensor to detect gamma radiation and to produce signal data, the ex vivo measurement sensor adapted to sensing gamma radiation proximate to a point of administration of the radioactive analyte on a subject;
- a signal amplifier in operable communication with the gamma radiation sensor, the signal amplifier adapted to amplify the signal data;
- at least one computer processor and a non-transient memory, the computer processor in operable communication with the non-transient memory and the amplified signal data;
- wherein the non-transient memory includes computer program code executable by the at least one computer processor, the computer program code configured for performing the steps of receiving the amplified signal data, accessing reference data corresponding to an administration protocol, comparing the amplified signal data to the reference data to determine a likelihood of improper administration of the radioactive analyte to the subject, and communicating an administration status to the auto-injection system.
A method for providing real-time feedback to an auto-injection system during administration to a subject of a radioactive analyte that decays in vivo, the method comprising:
- (i) applying at least one ex vivo gamma radiation measurement sensor proximate to a point of administration on the subject of the radioactive analyte;
- (ii) detecting gamma radiation over a desired period of time and producing signal data associated with the desired period of time;
- (iii) amplifying the signal data using a signal amplifier in operable communication with the ex vivo gamma radiation measurement sensor and outputting the amplified signal data;
- (iv) processing the amplified signal data using a computer processor in operative communication with a non-transient memory by performing the steps of:
- (a) receiving the amplified signal data associated with the desired period of time;
- (b) from the non-transient memory, accessing reference administration factors and reference data distributed over a reference period of time;
- (c) comparing the amplified signal data to the reference data and reference administration factors to determine a likelihood of improper administration of the radioactive analyte to the subject;
- and
- (d) communicating an administration status to the auto-injection system.
A method for providing real-time feedback to an administrator of a radioactive analyte that decays in vivo to a subject, the method comprising:
- (i) applying at least one ex vivo gamma radiation measurement sensor proximate to a point of administration on the subject of the radioactive analyte;
- (ii) detecting gamma radiation over a desired period of time and producing signal data associated with the desired period of time;
- (iii) amplifying the signal data using a signal amplifier in operable communication with the ex vivo gamma radiation measurement sensor and outputting the amplified signal data;
- (iv) processing the amplified signal data using a computer processor in operative communication with a non-transient memory by performing the steps of:
- (a) receiving the amplified signal data associated with the desired period of time;
- (b) from the non-transient memory, accessing reference administration factors and reference data distributed over a reference period of time;
- (c) comparing the amplified signal data to the reference data and reference administration factors to determine a likelihood of improper administration of the radioactive analyte to the subject;
- and
- (d) communicating an administration status to the administrator.
Dependencies are inferred from the claim text.