Single-use clinical spectrophotometer
AssigneeIn Diagnostics, Inc.
InventorOctavian Florescu
Life of this patent
Estimating the term…
Abstract
The single-use disposable spectrophotometer described in this disclosure can measure one or more blood chemistry analytes from a drop of whole blood. A passive filtration system takes whole blood and delivers plasma along with a dissolved reporter molecule to one or more spectrophotometers which can operate with narrow band optical spectrum centered on an optical detection frequency. The spectrophotometer detects the changes in absorption of the plasma as a result of a chemistry reaction to determine the concentration or activity of one or more analytes.
Claims18
A device for measuring the concentration or activity of one or more analytes comprising:
- a plasma comprising the analyte;
- a spectrophotometer;
- a filter mounted on a surface, wherein the filter comprises a plasma separation membrane;
- the surface fluidically connecting the filter with the spectrophotometer, wherein the device is configured so the plasma can flow directly from the filter onto the surface and into the spectrophotometer;
- wherein the spectrophotometer comprises a plurality of wells, and wherein the device is configured so the plasma flows from the surface into the wells, and wherein the wells are configured to contain the plasma,
- a reporter molecule dissolved in the plasma, wherein the reporter molecule is a product or reactant to a chemical reaction, and wherein the chemical reaction is homogeneous and label-free, and wherein the chemical reaction is limited by a concentration or an activity of the analyte in the plasma in the well;
- and
- wherein the spectrophotometer is configured to measure a rate of change or absolute change of the concentration of the reporter molecule in the plasma in the well, corresponding to the concentration or the activity of the analyte in the plasma in the well.
Dependencies are inferred from the claim text.