Process for identifying a stress state and/or for assessing the stress response level in a subject
AssigneesAdisseo France S.A.S., Centre National De La Recherche Scientifique
InventorsAlain Lescure, Luc Thomes, Yves Mercier, Mickaël Briens
Life of this patent
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Abstract
A process for identifying a stress state in a subject, for assessing the stress response level in a subject, for predicting the efficacy of an intervention solution in a subject, for monitoring the efficacy of an intervention solution in a subject and/or for identifying an intervention solution for a subject, having a step of detecting the expression and/or quantifying the expression level, in a sample of the subject, of at least four genes selected from a group made of twenty-six genes, as well as a kit having a way for amplifying and/or detecting the expression of the genes, and uses thereof.
Claims6
An in vitro process for identifying the presence or absence of a stress state in a subject being submitted to a challenge and/or for assessing the stress response level in a subject being submitted to a challenge comprising
- (a) detecting the expression and/or quantifying the expression level, in a sample of said subject, of at least four genes selected from the group consisting of Anxa1, Anxa2, Chac1, and Postn;
- and
- (b) administering to the subject at least one intervention solution to reduce or eliminate the stress state and/or stress response level in the subject, wherein
- the subject and the challenge are selected from:
- chickens subjected to heat stress,
- pigs subjected to heat and inflammatory stress,
- chickens subjected to a nutritional challenge, and
- mice subjected to a physical exercise challenge.
Dependencies are inferred from the claim text.