Riboregulators and methods of use thereof
AssigneesPresident and Fellows of Harvard College, Massachusetts Institute of Technology
InventorsLuis Ruben Soenksen Martinez, Nicolaas Angenent-Mari, Alexander S. Garruss, James J. Collins, George M. Church, Katherine Collins, Diogo M. Camacho
Life of this patent
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Abstract
This disclosure provides riboregulators specific for particular viruses or for particular human transcription factors. The viral-specific riboregulators may be used to detect the presence of the particular virus, and this may enable diagnosis of an infection. The transcription factor specific riboregulators may be used to detect the presence and/or measure the level of the particular transcription factor, and this may enable diagnosis or prognosis of a particular condition such as cancer.
Claims23
A toehold riboregulator having:
- (a) a nucleic acid sequence comprising any one of SEQ ID NOs:
- 43841, 9602, 62866, 19367, 164989, 111698, and 236638, or
- (b) nucleotides 21-103 of any one of SEQ ID NOs:
- 43841, 9602, 62866, 19367, 164989, 111698, and 236638, or
- (c) nucleotides 21-100 of any one of SEQ ID NOs:
- 43841, 9602, 62866, 19367, 164989, 111698, and 236638, or
- (d) RNA versions of (a), (b) or (c).
A plurality of toehold riboregulators comprising a toehold riboregulator comprising SEQ ID NO:
- 43841 and a toehold riboregulator comprising SEQ ID NO:
- 62866, or RNA versions thereof.
A plurality of toehold riboregulators, each comprising:
- (a) a nucleic acid sequence comprising SEQ ID NO:
- 43841 or SEQ ID NO:
- 62866, or
- (b) nucleotides 21-103 of SEQ ID NO:
- 43841 or SEQ ID NO:
- 62866, or
- (c) nucleotides 21-100 of SEQ ID NO:
- 43841 or SEQ ID NO:
- 62866, or
- (d) RNA versions of (a), (b) or (c).
Dependencies are inferred from the claim text.