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US 12,624,344 B2Granted
Variant polypeptides having enhanced activity of 3-methyl-2-oxobutanoate hydroxymethyltransferase and microorganisms for producing pantothenic or pantoic acid
AssigneeCj Cheiljedang Corporation
InventorsYee-Seul So, Kwang Soo Shin, Jihyun Shim, Kwang Woo Lee, Yeon-Jae Jang
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Abstract
A 3-methyl-2-oxobutanoate hydroxymethyltransferase variant, a microorganism having enhanced activity of 3-methyl-2-oxobutanoate hydroxymethyltransferase, a composition for producing pantothenic acid and/or pantoic acid comprising the microorganism, and a method for preparing pantothenic acid and/or pantoic acid comprising culturing the microorganism are provided.
Claims6
A polypeptide comprising an amino acid sequence having at least 95% sequence identity to SEQ ID NO:
- 37, wherein the amino acid at the position corresponding to position 159 of the polypeptide of SEQ ID NO:
- 37 is substituted with another amino acid,
- wherein the polypeptide has 3-methyl-2-oxobutanoate hydroxymethyltransferase activity.
Dependencies are inferred from the claim text.