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US 12,624,204 B2Granted
Ultra-high molecular weight polymers and methods of using the same
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsCullen L. Davidson, Wallace G. Sawyer, Brent S. Sumerlin, Juan M. Urueña Vargas
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Abstract
The present disclosure provides for compositions including at least one type of water-soluble polymer, methods of making the water-soluble polymer, structures having the water-soluble polymer disposed thereof, and methods of use thereof.
Claims26
A composition comprising:
- an ophthalmic aqueous solution including a first water-soluble polymer, wherein the first water-soluble polymer includes a plurality of backbone units and at least one first type of a mucin-binding unit, wherein the backbone units comprise greater than 50% of the first water-soluble polymer based on molecular weight, wherein the first type of mucin-binding unit comprises of 1 unit up to 50% of the first water-soluble polymer based on molecular weight, wherein the first type of mucin-binding unit comprises monomer units, copolymers that include the monomer units, or both, wherein the monomer unit includes a boronic acid group,
- wherein the first water-soluble polymer includes a second type of mucin-binding unit, wherein the second type of mucin-binding unit comprises monomer units, copolymers that include the monomer units, or both, wherein the monomer unit is selected from the group consisting of:
- acrylic acid, methacrylic acid, 4-vinylbenzoic acid, 4-(acrylamido)phenylboronic acid, 3-(acrylamido)phenylboronic acid, (2-(3-acrylamidopropanamido)phenyl) boronic acid (APAPBA), 2-(acrylamido)phenylboronic acid, 4-vinylphenylboronic acid, 3-vinylphenylboronic acid, 2-vinylphenylboronic acid, 2-(pyridin-2-yldisulfaneyl)ethyl methacrylate, pyridyl disulfide ethyl acrylate, pyridyl disulfide ethyl acrylamido, pyridyl disulfide alkyl (e.g. ethyl) methacrylamido, 2-(pyridin-2-yldisulfaneyl)ethyl acrylate, 2-(pyridin-2-yldisulfaneyl)ethyl acrylamido, 2-(pyridin-2-yldisulfaneyl)ethyl methacrylate, or 2-(pyridin-2-yldisulfaneyl)ethyl methacrylate, N-(2-(tritylthio)ethyl) acrylamide, a monomer including one or more boronic acid groups, a monomer containing one or more disulfide-forming groups, a halogenated versions of each of these, or a derivative of any one of these or copolymer of anyone of these, wherein the first type of mucin-binding unit is different than the second type of mucin-binding unit;
- wherein the first type of mucin binding unit comprises 1 functional unit to about 5% of the first water-soluble polymer based on molecular weight;
- wherein the second type of mucin binding unit comprises 1 functional unit to about 5% of the first water-soluble polymer based on molecular weight.
2 more elements
A composition comprising:
- an ophthalmic aqueous solution including a first water-soluble polymer, wherein the first water-soluble polymer includes a plurality of backbone units and at least one first type of a mucin-binding unit, wherein the backbone units comprise greater than 50% of the first water-soluble polymer based on molecular weight, wherein the first type of mucin-binding unit comprises of 1 unit up to 50% of the first water-soluble polymer based on molecular weight, wherein the first type of mucin-binding unit comprises monomer units, copolymers that include the monomer units, or both, wherein the monomer unit includes a boronic acid group, wherein the first type of mucin binding unit is located solely at one or both terminal ends of the first water-soluble polymer.
Dependencies are inferred from the claim text.