Compositions and methods for reducing off-target toxicity of antibody drug conjugates
AssigneeThe Research Foundation for The State University of New York
InventorsJoseph P. Balthasar, Brandon M. Bordeau, Toan Duc Nguyen, Joseph Ryan Polli
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Abstract
Provided are compositions and methods for reducing off-target toxicity of antibody-drug conjugates (ADCs). The compositions comprise an ADC, and an agent targeted to the drug (payload) that is delivered by or derived from the ADC. The ADC and the agent targeted to the payload may be delivered together or separately in the treatment of various conditions (such as tumors) by ADCs. Examples of agents targeted to payload include antibodies, fragments, or modifications thereof.
Claims11
A composition comprising an antigen binding antibody fragment and a pharmaceutical carrier, wherein the antigen binding fragment comprises the sequence of SEQ ID NO:3;
- or a heavy chain comprising the sequence of SEQ ID NO:4 and a light chain comprising the sequence of SEQ ID NO:5;
- or SEQ ID NO:6;
- or the sequence of SEQ ID NO:7;
- or the sequence of SEQ ID NO:
- 8;
- or the sequence of SEQ ID NO:9;
- or the sequence of SEQ ID NO:10;
- or the sequence of SEQ ID NO:
- 11;
- or the sequence of SEQ ID NO:69.
Dependencies are inferred from the claim text.