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US 12,624,097 B2Granted
Nucleic acids, vectors, and cells that encode anti-Sp17 antibodies and other Sp17 binding proteins
AssigneeMedicovestor, Inc.
InventorSeah Lim
Life of this patent
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Abstract
This disclosure describes proteins that specifically bind human sperm protein 17 (Sp17) with nanomolar affinity and high specificity. These proteins include a recombinant human anti-Sp17 IgG that is suitable for use as a therapeutic antibody to treat cancers that ectopically express Sp17. Other Sp17-binding proteins are described including antibody fragments, antibody conjugates, and fusion proteins.
Claims20
A recombinant nucleic acid, comprising a nucleotide sequence that encodes a protein that comprises an antigen-binding region, wherein:
- the antigen-binding region comprises a first variable domain and a second variable domain;
- wherein the first variable domain comprises a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 5, a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 6, and a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 7;
- and
- wherein the second variable domain comprises a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 8, a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 9, and a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 10;
- and
- wherein the first variable domain and the second variable domain are paired in the antigen-binding region of the protein such that the antigen-binding region specifically binds human sperm protein 17 (Sp17).
9 more elements
Dependencies are inferred from the claim text.