Monoclonal antibodies against pathological tau, and methods of detection thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsGarrett S. Gibbons, Dawn M. Riddle, John Q. Trojanowski, Virginia M.Y. Lee
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Abstract
The present disclosure provides monoclonal antibodies that selectively bind to pathological tau over native tau. In certain aspects, the antibodies inhibit or minimize propagation of tau aggregates and/or reduce spread of pathological tau in vivo. In other aspects, the disclosure comprises a method of treating, ameliorating, and/or preventing a tauopathy in a subject, comprising administering any one of the antibodies of the disclosure to the subject. In yet other aspects, the disclosure comprises methods of detecting pathological tau using any one of the antibodies of the disclosure.
Claims11
An isolated monoclonal antibody comprising a light chain variable region (VL) and a heavy chain variable region (VH), wherein:
- (a) the VL comprises
- a Complementarity-Determining Region 1 (CDR1) region comprising the amino acid sequence of SEQ ID NO:
- 23;
- a Complementarity-Determining Region 2 (CDR2) region comprising the amino acid sequence of SEQ ID NO:
- 25;
- and
- a Complementarity-Determining Region 3 (CDR3) region comprising the amino acid sequence of SEQ ID NO:
- 27, and
- the VH comprises
- a CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 9;
- a CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 11;
- and
- a CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 13, or
- (b) the VL comprises
- a CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 51;
- a CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 53;
- and
- a CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 55, and
- the VH comprises
- a CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 37;
- a CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 39;
- and
- a CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 41.
Dependencies are inferred from the claim text.