Ehrlichia vaccines and immunogenic compositions
AssigneesResearch Development Foundation, Zoetis Services LLC
InventorsJere W. McBride, Paul J. Dominowski, Suman Mahan, Jason J. Millership, Duncan M. Mwangi, Sharath Rai, Sharon M. Wappel
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Abstract
Provided herein are immunogenic compositions that may be used, in some aspects, to induce an immune response against an Ehrlichia such as Ehrlichia canis. In some embodiments, the immunogenic composition comprises an E. canis bacterin and/or adjuvant, such as for example an emulsion or liposomal adjuvant. Related methods such as for diagnosis of or vaccination against ehrlichiosis are also provided.
Claims7
An immunogenic composition comprising a suspension of an Ehrlichia canis bacterin and a combination of immunogenic tandem repeat proteins (TRP) consisting of isolated TRP36, TRP140 and TRP19 proteins of Ehrlichia canis, a pharmaceutically acceptable excipient, and an adjuvant formulation consisting of a purified or partially purified immunologically active saponin prepared from the bark of Quillaja saponaria, cholesterol, and a CpG-containing ODN, wherein the Ehrlichia canis bacterin is inactivated with binary ethyleneimine (BEI).
Dependencies are inferred from the claim text.