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US 12,624,092 B2Granted
Compositions and methods for membrane protein structure determination
AssigneeThe Regents of the University of Michigan
InventorsBenjamin C. McIlwain, Randy B. Stockbridge
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Abstract
Disclosed herein are compositions and methods for determining the structure of a membrane protein. An epitope from a membrane-proximal external region (MPER) from a viral envelope protein can be grafted on to a variety of diverse membrane proteins to allow for binding structurally characterized antibody fragments, which can aid structural studies.
Claims10
A complex comprising:
- (a) a MPER peptide fusion protein comprising formula A-B, wherein:
- A is a peptide having consisting of the sequence of SEQ ID NO:
- 1;
- and
- B is membrane protein;
- and
- (b) an antibody fragment that binds to the peptide A.
4 more elements
Dependencies are inferred from the claim text.