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US 12,624,088 B2Granted
Chimeric receptor comprising a ligand binding domain and an endodomain comprising a cytokine receptor endodomain and an intracellular T cell signalling domain
AssigneeAutolus Limited
InventorsMartin Pulé, Shaun Cordoba, Matteo Righi
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Abstract
The present invention provides a chimeric receptor which comprises: a ligand-binding exodomain; and an endodomain which comprises: (i) a cytokine receptor endodomain; and (ii) an intracellular T cell signalling domain.
Claims21
A chimeric receptor comprising:
- a ligand-binding exodomain that comprises an antigen binding domain of an antibody;
- a transmembrane domain;
- and
- an endodomain which comprises:
- (i) a cytokine receptor endodomain, wherein the cytokine receptor endodomain comprises or consists of an IL-2 receptor β-chain endodomain;
- and
- (ii) an intracellular T cell signalling domain that includes a CD3 zeta endodomain.
4 more elements
Dependencies are inferred from the claim text.