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US 12,624,087 B2Granted
CD155 variant immunomodulatory proteins and uses thereof
AssigneeAlpine Immune Sciences, Inc.
InventorsRyan Swanson, Michael Kornacker, Daniel William Demonte, Mark F. Maurer
Life of this patent
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Abstract
Provided herein are immunomodulatory proteins comprising variant CD155 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
Claims22
A variant CD155 polypeptide comprising an amino acid sequence that exhibits at least 90% sequence identity to SEQ ID NO:
- 47 or amino acid residues 4-199 of SEQ ID NO:
- 47, wherein the variant CD155 polypeptide comprises the amino acid substitution L104Q with reference to positions set forth in SEQ ID NO:47 of unmodified CD155;
- wherein the variant CD155 polypeptide specifically binds to the ectodomain of TIGIT with increased affinity compared to that of the unmodified CD155.
Dependencies are inferred from the claim text.