Chimeric antigen receptors against human cytomegalovirus
AssigneesThe Regents of the University of California, City of Hope
InventorsOtto O. Yang, Ayub Ali, Don J. Diamond, Flavia Chiuppesi, Felix Wussow
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Abstract
Disclosed herein are CMV-specific CARs. In some embodiments. the present invention is directed to a method of treating, reducing, or inhibiting an infection by a cytomegalovirus in a subject, which comprises administering to the subject (a) an expression vector that encodes a CMV-specific CAR as described herein, or (b) one or more cells that are transduced with the expression vector.
Claims17
A cytomegalovirus specific chimeric antigen receptor (CMV-specific CAR), which comprises a single chain antibody (scFv) sequence having the following CDR sequences:
- VH CDR1-SEQ ID NO:
- 30,
- VH CDR2-SEQ ID NO:
- 39,
- VH CDR3-SEQ ID NO:
- 46,
- VL CDR1-SEQ ID NO:
- 59,
- VL CDR2-SEQ ID NO:
- 66, and
- VL CDR3-SEQ ID NO:
- 71.
A cytomegalovirus specific chimeric antigen receptor (CMV-specific CAR), which comprises or consists of SEQ ID NO:
- 89.
Dependencies are inferred from the claim text.