Engineering broadly reactive human notch ligands as novel tools for biomedical applications
AssigneeH. Lee Moffitt Cancer Center and Research Institute, Inc.
InventorsVincent Luca, David Gonzalez Perez
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Abstract
Disclosed are compositions and methods for engineered DLL4 proteins. In one aspect, disclosed herein are engineered DLL4 proteins comprising a conservative amino acid substitution at a residue corresponding to residues 28, 107, 143, 194, and 206 as set forth in SEQ ID NO: 1 and further comprising at least one conservative amino acid substitution at residues 256, 257, 271, 280, 301, and 305 as set forth in SEQ ID NO: 1.
Claims20
An engineered DLL4 protein comprising a conservative amino acid substitution at a residue corresponding to residues 28, 107, 143, 194, and 206 as set forth in SEQ ID NO:
- 1 and further comprising at least one conservative amino acid substitution at residues 256, 257, 271, 280, 301, and 305 as set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.