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US 12,624,049 B2Granted
Salt and crystal forms of 4-amino-5-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-z-yl)thieno[2.3-b]pyridin-6(7H)-one
AssigneeUniversity Health Network
InventorsMark R. Bray, Sze-Wan Li
Life of this patent
Estimating the term…
Abstract
A novel salt form of Compound (I) represented by the following structural formula, and its corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1 Compound (I) tartrate salt are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms are also disclosed. The present disclosure also provides methods of treating cancer in a subject.
Claims12
A tartrate salt of Compound (I) represented by the following structural formula:
- wherein the molar ratio between Compound (I) and tartaric acid is 1:1, wherein the tartrate salt is in a single crystalline form, characterized by an X-ray powder diffraction pattern which comprises at least three peaks chosen from 11.9°, 15.4°, 16.9°, 17.2°, and 25.6°±0.2 in 2θ.
Dependencies are inferred from the claim text.