14-chloro-β-elemene nitric oxide donor derivative and preparation method and use thereof
AssigneeHangzhou Normal University
InventorsTian Xie, Renren Bai, Xiangyang Ye, Junlong Zhu, Ziqiang Bai
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Abstract
Disclosed are a 14-chloro-β-elemene nitric oxide donor derivative and a preparation method and use thereof in the preparation of anti-tumor drugs. The 14-chloro-β-elemene nitric oxide donor derivative has a general formula shown in formula (I): in formula (I): R1 represents a linear or cyclic alcohol amine structure containing nitrogen and oxygen atoms; and each of R2 and R3 is independently selected from the group consisting of C1-10 alkyl, C3-12 cycloalkyl, C6-12 aryl, 5- to 10-membered cyclic heteroaryl, C2-10 alkenyl, C2-10 alkynyl, and C2-10 alkoxy.
Claims10
A 14-chloro-β-elemene nitric oxide donor derivative, or a pharmaceutically acceptable salt, a solvate, an enantiomer, or a diastereoisomer thereof,
- the 14-chloro-β-elemene nitric oxide donor derivative having a structural general formula as shown in formula (I):
- wherein in formula (I),
- R1 is any one selected from the group consisting of
- and
- each of R2 and R3 is independently selected from the group consisting of C1-10 alkyl, C3-12 cycloalkyl, C6-12 aryl, 5- to 10-membered cyclic heteroaryl, C2-10 alkenyl, C2-10 alkynyl, and C2-10 alkoxy.
Dependencies are inferred from the claim text.