Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway

A compound of formula (I′)

• or a stereoisomer, a racemic mixture, a tautomer, a polymorph, a pharmaceutically acceptable salt, a prodrug, a hydrate, or a solvate thereof;
• wherein
• X is independently selected from the group consisting of O, N and S;
• Y is independently selected from the group consisting of N and O;
• as valency permits, is a combination of a single bond and a double bond or is two single bonds;
• n is 1 or 2;
• R0 is H or C1-C3alkyl;
• R1 is
• wherein
• Z is independently selected from the group consisting of CH2 and O provided that no more than two of Z are O;
• R5 is independently selected from the group consisting of hydrogen and halogen;
• R2 is independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C6cycloalkyl;
• and
• R3 is independently selected from the group consisting of heteroC3-C6cycloalkyl, aryl or heteroaryl, wherein each of them can be optionally substituted with —C1-C6alkyl, —O—C1-C6alkyl, -Hal, or —C1-C6alkyl-OH.