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US 12,624,003 B2Granted
Carboxylic acid containing indanyl compounds for the treatment of neurodegenerative diseases
AssigneeCelgene Corporation
InventorsJeffrey M. Schkeryantz, Julie Selkirk, Philip Stewart Turnbull, Junko Tamiya, Patrick W. Papa, Jean-Francois Brazeau, Karin Worm
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Abstract
Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases.
Claims19
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- L is —C(Y)C(X)— or a bond;
- X and Y are independently H, O, H2, or absent;
- is a single, double, or triple bond;
- R1 is C6-C10 aryl, fused bicyclic 8- to 10-membered heteroaryl, or fused bicyclic 8- to 10-membered heterocyclyl, each of which is optionally substituted by 1-5 R′ groups, wherein the heterocyclyl and heteroaryl contain 1-3 heteroatoms selected from nitrogen and oxygen;
- each R′ is independently halo, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, or C3-C6 cycloalkyl;
- R2 is H or C1-C6 alkyl;
- R3 is —(CH2)x—CO2H or
- or the dashed line between R2 and R3 represents a ring structure where R2 and R3 are taken together with the nitrogen atom to which they are attached to form a 4- to 6-membered heterocyclyl substituted by 1-5 R4 groups, wherein at least one R4 group is —CO2H or contains a —CO2H moiety;
- x is 1-5;
- and
- each R4 is independently —CO2H, halo, or C1-C6 alkyl,
- or two R4 groups are taken together with the carbon atoms to which they are attached to form a fused, bridged, or spiro C3-C5 cycloalkyl optionally substituted by —CO2H.
10 more elements
A compound selected from:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.