Transcutaneous electrical spinal cord neuromodulator and uses thereof
AssigneesThe Regents of the University of California, Scoula Internazionale Superiore di Studi Avanzati—Sissa, University of Southern California
InventorsParag Gad, Victor Reggie Edgerton, Giuliano Taccola, Evgeniy I. Kreydin
Life of this patent
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Abstract
In various embodiments electrical stimulators are provided for transcutaneous and/or epidural stimulation. In certain embodiments the stimulator provides one or more channels configured to provide one or more of the following stimulation patterns: i) monophasic electrical stimulation with a DC offset; ii) monophasic electrical stimulation with charge balance; iii) delayed biphasic electrical stimulation with a DC offset; iv) delayed biphasic electrical stimulation with charge balance; v) amplitude modulated dynamic stimulation; and/or vi) frequency modulated dynamic stimulation.
Claims14
A transcutaneous electrical spinal cord stimulator, said stimulator comprising:
- a plurality of array electrodes configured to be placed in contact with an outer skin surface of a patient directly over a spinal cord on a back positioned between vertebral processes;
- a pulse modulator unit connected to the microprocessor;
- one or more channels configured to provide one or more transcutaneous electrical spinal cord stimulation patterns, via the plurality of array electrodes, to a plurality of nerves in the spinal cord to provide therapy for a disorder of a connection between a brain and a spinal cord of a patient, at least one of which includes a plurality of delayed biphasic electrical stimulation pulses;
- a microprocessor unit in communication with the plurality of array electrodes, the pulse modulator unit, and the one or more channels;
- and
- a memory in communication with the microprocessor unit and having instructions stored thereon that, when executed, cause the microprocessor unit to:
- receive a plurality of treatment parameters corresponding to the one or more electrical spinal cord stimulation patterns, wherein the plurality of treatment parameters comprises a motor threshold;
- execute the plurality of treatment parameters using the plurality of array electrodes and the pulse modulator unit;
- detect an EMG response;
- and
- store the plurality of treatment parameters,
- wherein the motor threshold comprises an intensity that excites or inhibits certain neurons or interneurons within the spinal cord to treat connectivity impaired by the disorder of the connection between the brain and the spinal cord of the patient, wherein said neurons or interneurons are remote from a site of said stimulation;
- and
- wherein the plurality of delayed biphasic electrical stimulation pulses includes an anodic phase and a cathodic phase configured to independently provide therapy to the spinal cord.
Dependencies are inferred from the claim text.