Wound dressing compositions and uses thereof
AssigneeSystagenix Wound Management, Limited
InventorsAlexander Waite, Carrina Ward
Life of this patent
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Abstract
The present disclosure relates generally to wound dressing compositions that detect nitric oxide production in a wound upon application. The wound dressing composition comprises a first layer comprising an absorbent layer, a second layer comprising a reaction pad, a third layer comprising a transparent backing film, and optionally a fourth layer comprising a wicking layer. In the wound dressing composition, the second layer comprises a reaction pad of a dried reaction mixture to detect the presence of nitric oxide in a wound. The wound dressing composition can be a visual indicator of the presence of nitric oxide in a wound; a visual indicator of the wounds healing status.
Claims20
A wound dressing composition comprising a first layer, a second layer, and a third layer:
- wherein each of the first layer, the second layer, and the third layer comprises a wound-facing side and an environmental-facing side;
- wherein the first layer comprises an absorbent layer;
- wherein the second layer comprises a reaction pad including a first reagent configured to react with a second reagent to provide a first color intensity change indicating the presence of nitric oxide, wherein the first reagent is further configured to react with the second reagent to provide a second color intensity change, with continued exposure to wound fluid in the wound dressing, after the first color intensity change, and wherein a ratio of the first reagent to the second reagent is about 10:1;
- and
- wherein the third layer comprises a transparent backing film, and wherein the second layer is positioned between the first layer and the third layer, the third layer further comprising a colorimetric indicator strip including a plurality of colors correlated to a quantity of nitric oxide indicated by the first color intensity change and the second color intensity change of the second layer, wherein the plurality of colors include at least a first color intensity correlating to a first nitric oxide quantity, a second color intensity correlating to a second nitric oxide quantity that is greater than the first nitric oxide quantity, and a third color intensity correlating to a third nitric oxide quantity that is greater than the first nitric oxide quantity and the second nitric oxide quantity.
A method for making a wound dressing composition comprising:
- providing a first layer, a second layer, and a third layer;
- and
- combining the first layer, the second layer, and the third layer to make the wound dressing composition,
- wherein each of the first layer, the second layer, and the third layer comprises a wound-facing side and an environmental-facing side;
- wherein the first layer comprises an absorbent pad;
- wherein the second layer comprises a reaction pad;
- and
- wherein the third layer comprises a transparent backing film.
A method for making a wound dressing composition comprising:
- providing a first layer, a second layer, a third layer, and a fourth layer;
- and
- combining the first layer, the second layer, the third layer, and the fourth layer to make the wound dressing composition,
- wherein each of the first layer, the second layer, the third layer, and the fourth layer comprises a wound-facing side and an environmental-facing side;
- wherein the first layer comprises an absorbent pad;
- wherein the second layer comprises a reaction pad;
- wherein the third layer comprises a transparent backing film;
- and
- wherein the fourth layer comprises a wicking layer.
Dependencies are inferred from the claim text.